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Latrunculin A
The latrunculin class of marine sponge derived natural products represent one of the most potent and widely used chemical probes involving microfilament assembly that target G-actin in cell and molecular biology studies (3).
Source: Cacospongia mycofijiensis
Purity: >98% (HPLC) MW: 421.5 MF: C22H31NO5S CAS No. 76343-93-6
Product availability: 1 mg, 5 mg, 10 mg, 20 mg - $500 / 1mg
PRODUCTS
We serve as a high quality wholesale distributor of discounted marine sponge-derived natural products using advanced purification and spectroscopic methods which we have published previously (1-2). Purity is assured using LC-MS and 1H NMR data included with every batch number. We specialize in a select number of the most potent marine sponge derived natural product inhibitors of the cell cycle which include the following wholesale discounted products.
CONTACT US for a FREE 100 ug Promotional Sample to confirm our Certificate of Analysis.
F- actin
Jasplakinolide
G- actin
Jasplakinolide is one of the most potent molecular probes for the inhibition of microfilament assembly targeting F-actin.
Source: Jaspis splendens
Purity: >98% (HPLC) MW: 709.1 MF: C36H45BrN4O6 CAS No.102396-24-7
Product availability: 1 mg, 5 mg, 10 mg, 20 mg - $1000 / 1mg
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Laulimalide (aka fijianolide B) is a novel chemical probe microtubule stabilizer that functions at a binding site distinct from Taxol. It is a potent inhibitor of cellular proliferation in various cancer cell lines (IC50: 3-30 nM). The compound causes cells to arrest in prometaphase of the cell cycle, prevents formation of the bipolar spindle and increases kinetochore tension in preformed spindles (4-5).
Source: Cacospongia mycofijiensis
Purity: >98% (HPLC) MW: 514.6 MF: C30H42O7 CAS No.115268-43-4
Produce availability: 1 mg - $2000 / 1mg (contact us for pricing)
Microtubule stabilizer
Laulimalide (aka fijianolide B)
1) Johnson, T. A.; Morgan, M.; Aratow, N.; Estee, S. A.; Sashidhara, K. V.; Loveridge, S.; Segraves, N. L.; Crews, P.
Assessing Pressurized Solvent Extraction for the High-Throughput Extraction of Marine-Sponge-Derived Natural Products.
Journal of Natural Products, 2010, 73, 359.
2) Johnson, T. A.; Sohn, J.; Inman, W.D.; Estee, S. A.; Loveridge, S. T.; Vervoort, H. C.; Tenney, K.; Liu, J.; Ang, K. K.; Ratnam, J.; Bray, W. M,; Gassner, N. C.; Shen, Y. Y.; Lokey, R. S.; McKerrow, J. H.; Boundy-Mills K.; Nukanto, A.; Kanti, A.; Julistiono, H.; Kardono, L. B.; Bjeldanes, L. F.; Crews P.
Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads.
Journal of Natural Products, 2011, 74, 2545.
3) Amagata, T.; Johnson, T.A.; Cichewicz, R.H.; Tenney, K.; Mooberry, S.L.; Media, J.; Edelstein, M.; Valeriote, F.A.; Crews, P.
Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges.
Journal of Medicinal Chemistry, 2008, 28, 7234.
4) Morris, J. D.; Takahashi-Ruiz, L.; Persi, L. N.; Summers, J. C.; McCauley, E. P.; Chan, P. Y. W.; Amberchan, G.; Lizama-Chamu, I.; Coppage, D. A.; Crews, P.; Risinger, A. L.; Johnson, T. A.
Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs.
ACS Omega, 2022,7 (10), 8824-8832
5) Johnson, T.A.; Tenney, K.; Cichewicz, R.H.; Morinaka, B.I.; White, K.N.; Amagata, T.; Subramanian, B.; Media, J.; Mooberry, S.; Valeriote, F.A.; Crews, P.
Sponge-derived Fijianolide (syn. Laulimalide) Polyketide Class: Further Evaluation of their Structural and Cytotoxic Properties.
Journal of Medicinal Chemistry, 2007, 16, 3795.
6) Morgan, J. B.; Mahdi, F.; Liu, Y.; Coothankandaswamy, V.; Jekabsons, M. B.; Johnson, T. A.; Sashidhara, K. V.; Crews, P.; Nagle, D. G.; Zhou, Y. D.
The Marine Sponge Metabolite Mycothiazole: a Novel Prototype Mitochondrial Complex I Inhibitor.
Bioorganic & Medicinal Chemistry, 2010, 18(16), 5988–5994
7) Dutta, N.; Gerke, J.A.; Odron, S.F.; Morris, J.D.; Hruby, A.; Kim, J.; Torres, T.C.; Shemtov, S.J.; Clarke, J.G.; Chang, M.C.; Shaghasi, H.; Ray, M.N.; Averbukh, M.; Hoang, S.; Oorloff, M.; Alcala, A.; Vega, M.; Mehta, H.H.; Thorwald, M.A.; Crews, P.; Vermulst, M.; Garcia, G.; Johnson, T.A.; Higuchi-Sanabria, R.
Investigating Impacts of the Mycothiazole Chemotype as a Chemical Probe for the Study of Mitochondrial Function and Aging.
Geroscience, 2024, 46(6), 6009–6028.
8) Johnson, T. A.; Morris, J. D.; Coppage, D. A.; Cook, C. V.; Persi, L. N.; Ogarrio, M. A.; Garcia, T. C.; McIntosh, N. L.; McCauley, E. P.; Media, J.; Maheshwari, M.; Valeriote, F. A.; Shaw, J.; Crews, P.
Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration.
ACS Medicinal Chemistry Letters, 2020, 11(2), 108–113.
9) Takahashi-Ruiz, L.; Morris, J.D.; Crews, P.; Johnson, T.A.; and Risinger, A.L..
In Vivo Evaluation of (-)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site.
Molecules, 2022, 27(13), 4244.
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8-OAc mycothiazole
Zampanolide
Mitochondiral Complex I Inhibitor
Microtubule stabilizer
8-OAc mycothiazole is a semi-synthetic analog of the marine sponge-derived natural product mycothiazole, a potent mitochondrial Complex I inhibitor. This acetylated derivative retains nanomolar potency against various cancer cell lines and exhibits improved chemical stability over its natural counterpart. As a molecular probe, 8-OAc mycothiazole enables the study of mitochondrial metabolism, oxidative phosphorylation, and aging-related processes in both cancer and model organisms (6-8).
Source: Cacospongia mycofijiensis
Purity: >98% (HPLC) MW: 447.1 MF: C24H34N2O4S CAS No. 1247068-69-4
Produce availability: (contact us for pricing)
Zampanolide is a highly potent, covalent microtubule stabilizing agent that binds irreversibly to the taxane site on β-tubulin. This compound exhibits nanomolar activity across multiple cancer cell lines and is active against multidrug-resistant phenotypes such as Taxol. Zampanolide arrests cells in mitosis by promoting the formation of stable, non-functional microtubules and has been widely used to study microtubule dynamics (9).
Source: Cacospongia mycofijiensis
Purity: >98% (HPLC) MW: 495.6 MF: C29H37NO6 CAS No.
Produce availability: (contact us for pricing)
